Use Barnes TSX or Barnes TTSX.... no matter what grain bullet or caliber you shoot from 243 to 338 magnum, there is not a better bullet out there!!!! I can promise you, you will not be disappointed! My dad and I switched to these bullets 3 years ago, and haven't looked back. We do handload our on stuff. I shot a 230lb 9 point two years ago with a 150 grain 300WSM at about 225 yards, the deer was facing me and it went through the front left shoulder and exited the back right hind quarter. My dad shoots a 7mm08 religously and he's shot doe after doe through both shoulders out to 300 yards with a 140 grain and has had all pass throughs. This bullet mushrooms really good and goes all the way through whatever youre shooting! I used to shoot nosler ballistic tips also but they don't compare to the Barnes. Also, the meat wil not be tore up even with shoulder shots with this bullet.