I would never take that shot. Not that I cant make it (I shoot regularly at our 600 yard range at the farm) but if something goes wrong and I wound deer and am unable to recover it I would be sick. I am not hunting for subsistence. I can buy food at the grocery store so there is absolutely no reason for me to take a poor shot. I have let many deer walk that I couldnt get a good shot.

Others will do different. But people who make these types of shots will inevitably be a little off and just wound a deer, others have mentioned blowing a jaw off, and the death that awaits that deer is horrible.