Shoulder shots or right behind create the highest probability of a clean kill and recovery. A 150 grain or more bullet gives one a slight increase of doing more damage than even a 100 grain. There is very little meat loss on a deer with those shots. For the most meat to go in the freezer only shoot 120 pound or larger deer. Those small ones really are a waste of time. I just wouldn't take head shots due to the probability of slight movement on the shooter or the deer and it may end up running around without a jaw.