I’d say whichever has the better BC. Are you stuck with only those two choices? I think there are some better projectiles available.
BC means nothing to 95%+ of all hunters. Shoot what your rifle likes. I've got experience with both the Pro Hunters and Speers in 243. ProHunters shoot better for me but I don't normally get an exit so I wait for better shots. The Speers aren't quite as accurate but seem to be tougher. Both kill.