I have killed several deer with a handgun. My favorite is .357. I have killed them with .38, .357, .41, .44, .45 and maybe a couple of more I can't remember. My most memorable moment was not hunting but shooting a Ruger .44. t was memorable for all the wrong reason. I was 17 yo. Grabbed the pillow off my bed to shoot off of in the backyard. Mom, "Boy, where are you going with that pillow?" Aw, just out back to shoot my new pistol. "You better not mess up that pillow!!" I lay that pillow up on the toolbox on my truck and take a few shots with my hand and gun resting in the pillow. I walk down and check the target. When I turn around that pillow is on fire on my truck. Guess the muzzle blast set it on fire. Mom wasn't happy!!