You have to "see" the path thru the deer the head will take and adjust yer exterior hide hit accordingly.

I killed a big old seven point onct that was bedded at 49 yards with a hot doe. He was almost broadside and slightly above me. I ranged him, held low with the 50 yard pin(compound days) and hit him low, angling up. He struggled to his feet and fell, so I put another one in him. He never got back up.

I killed an 1800# Eland in Zimbabwe from a bad angle. He was bedded under a lone tree at 150 yards. 45 degree angle away to the right. Body "rolled" over towards me. I hit him just in front of the right hip, 3/4 way up the body. Bullet found in front of left shoulder. LOTS of penetration, gun was a 375H&H. Eland raced to his feet and was gone, made 200 yards and down running.