my daughter has killed 3 in the last 2 years with a 223. the load i use is a 80 vld berger. also use 80 amax . with a holland tight neck reamer and 26 in kriger barrel i can get 3000 fps. last deer she shot was 174 yards and drt. for the 22-250 if you have a 9 twist or faster a 62 gr barnes x is a great load. i have killed lots of does with that load.