This is my opinion, A 22-250 will kill them just as dead as any with the right shot. I am a .270 and .243 man my self. A .270 will push a 130 grain basically as fast as a .223 will a 55 grain. that's like a .243 shoot 100 grain in deer season and .55 grain in off season. A 55 grain in 243 will faster and flatter than a 22-250. just my .02

"You do and it will be the biggest mistake you ever made, you Texas brush popper" John Wayne