Mine is a 2018. It started “chirping” almost like a belt or pulley, to the point I changed belts and water pump. Chirp eventually turned into more of a knocking and missing. My #3 lifter was bad and ate into the cam. Went back with all new lifters and cams, seals, valves, oil pump, re-machined head and deleted the fuel management system and required some tuning.
I haven’t had the truck back very long but it’s driving great and my mpg is as good as when it was dropping 4 cylinders prior to the delete.
If I had it to do over, I would do the delete as soon as my factory warranty went out. I’m not sure if it would have prevented one of those lifters from going out, but maybe extend its life a little. I do feel like what I’ve done now should eliminate that problem going forward.