I killed a doe with mine using the Winchester 180 grain load. Piled her up at a little over 80 yards. Lots of blood.

I'm also pretty partial to 300 BO using 110 Gr Nosler Varmageddon. Shot a big boar hog in the PigBrig trap with that load at about 50 yards Saturday morning. Folks with me were pretty impressed with how fast he went down. Mine is the Ruger American with the 16" barrel and has zero recoil.