My Prohunter has alway shot the TC Shockwave 200 gr extremely well over 100 gr of 777 or 110 gr of BH209. Flat shooting and good penetration. Every deer I've shot with it has fallen within 50 yards, including a good 8 point shot slightly quartering to at ~80 yards. Bullet hit junction of front shoulder and neck, came out around next to last rib. Back in the day, dropped many a deer using saboted 240 gr XTP over 100 gr of pyrodex. Have also shot numerous deer using the POWERBELT 245gr .50cal Copper Aerotip. Accurate but penetration was spotty and would often break up.

Sometimes it's hit or miss on a blood trail even with modern firearms. Always helps to have an entrance and exit hole. Would hypothesize the larger the holes are, the less likely is it of getting plugged w/ fat, hair, skin, etc..