Basically, for the first 18-24 months they don't have any symptoms that you can see, then they start losing weight and all their bodily functions start to go till eventually they're walking around with their head down drooling. Here's a couple links to a buck and cow elk near the end game: Whitetail buck with CWD. Cow elk with CWD


Per the USGS:

"What are the visual signs of chronic wasting disease?

Chronic wasting disease (CWD) has an extended incubation period averaging 18–24 months between infection and the onset of noticeable signs. During this time frame animals look and act normal. The most obvious sign of CWD is progressive weight loss. Numerous behavioral changes also have been reported, including decreased social interaction, loss of awareness, and loss of fear of humans.Diseased animals also may exhibit increased drinking, urination, and excessive salivation."