It's all I have hunted with for the last 20 or so years. I shoot Federal Premium Vital Shock 115 gr. Nosler Partitions out of it and deer have a habit of dying from it. With that weight of bullet there's not much kick and vitals get destroyed. There's lots of calibers that will do the same though, but I love my 25.06 above everything else in my safe. Everyone that I personally know that have them, love them.