If he's close to an area I don't want him to run in to, such as swamp or very thick cutover, I'm aiming dead for the bottom of the M and break his shoulders down. I've had to retrieve deer from both the described places on the land I hunt and neither is fun. Now if I were bow hunting I'd aim for the bottom right of the O.

I don't care about saving the shoulder meat. A mature buck like that I'd probably donate to the feed the hungry program anyways.