IMO, a 5.0L F150 is the most reliable half ton truck since the Tundras changed.
I currently have a 2013 (285k miles) and a 2023 (90k miles). Had another 2013, sold it around 260k miles because it started randomly losing power and the mechanic couldn't figure it out. Had a 2016 that I sold at 120k miles with no issues. Standard maintenance on all those, no issues/repairs other than the one I mentioned.
Out of curiosity, when you say "randomly lose power", would it basically idle all the way down until it shut off? Usually at a stoplight? But then crank back up?
Mine did that about 2-3 times/year for a few years. Finally, Spring 2025, it died and wouldn't crank up. It was the fuel pump. And the fuel pump in that truck is an absolute SOB to change. It's in the tank, so your choices are pull the bed or drop the tank.
There are either 6 or 8 bolts holding the bed on - they're huge torx head bolts. But the problem is that the nut is tack-welded on the
inside of the fully enclosed frame and you'll almost NEVER get all of them out without at least one nut breaking loose and spinning inside the frame. So then you gotta cut the bolt, then you gotta cut the frame open and re-weld a new nut, then weld the frame back closed.
All of that is to say, dropping the tank is the easier route....but then, it's a SOB too....there are connections that have to be disconnected in order to drop the tank, but you pretty much have to drop the tank to get to them (catch-22). And inevitably, the fuel pump will die when you've got a full tank and it weighs 17,000 pounds