I don't have experience with it, but if you can get it in a black bag, put it out in the sun and I'd think that there is no way they could survive that. Maybe just bag it and leave it on the limb. I have a buddy (crazy roofer) that got one down from the eave of a house. I watched from a distance as stood on an 8 ft ladder and held a can of wasp spray inches from the hole and emptied the can. I am not sure if that would degrade the nest or not.