I'm sure I'll get scolded and corrected for this and I bet I could name who it will come from but, my thinking is the high BC bullets penetrate so well due to the high SD that they are through most Alabama sized whitetails before they can expand to maximum diameter. Hence why the 6.5 140s do so well penetrating moose and elk sized game. The bullets that are softer often times tend to fragment or explode doing massive internal damage without exiting. The light for caliber mono bullets can be driven faster and the Barnes LRX is designed to open at much less speed that the TTSX, therefore it "SHOULD" open easier/sooner. I've often wondered it a traditional cup and core lead nose bullet in the 120-130 grain range would perform better on deer. Likewise, a 200 grain Accubond out of a 30-06 will kill one, but a 150 or 165 grain Accubond will perform better with the same shot placement due to the higher impact velocity and the lower BC & SD allowing the bullet to mushroom sooner and at a faster rate.