Me personally I wouldn't try running by just a GPS but I live on Seminole with 10 million stumps so I'm kinda paranoid about running when I can't see. Last year I busted the drive shaft on my 250 pro xs and I could clearly see where I was going and had run that spot a thousand times and still hit a stump. First trip out after getting a new lower unit I hit a floating log just under the surface running about 45 and that was a sick feeling for sure. Luckily it was a small floating log that was kinda rotten and I just cut it in half with no damage to the boat. I know some guys that do run by GPS alone but I just don't feel comfortable doing it.