Last year I was watching a doe and fawn hanging out 100 yards from my stand. On another shooting lane a coyote was coming in and he was about 100 yards from them and 100 yards from me with a rise between them. I put the crosshairs on him as he stopped for a second. He took a 140 grain bullet between the eyes and other then some kicking it was over. The doe and fawn stuck around for another 20 minutes before moving along. Don't be afraid of ruining your hunt by shooting a coyote.
I tried to find the study I referenced earlier but couldn't find it. It was over ten years ago but if I remember correctly it was done by a game biologist working at U.C. Davis.